CVE-2022-21126

Name: CVE-2022-21126
Creator: NVD / NIST
Published: 2022-11-29T17:15:11.043+00:00
License: https://creativecommons.org/publicdomain/zero/1.0/

HIGHCVSS 7.8/10EPSS 0.70%

Last modified Jun 17, 2026

CVE-2022-21126 is a high-severity vulnerability rated 7.8/10 on the CVSS scale. The package com.github.samtools:htsjdk before 3.0.1 are vulnerable to Creation of Temporary File in Directory with Insecure Permissions due to the createTempDir() function in util/IOUtil.java not checking for the existence of the temporary directory before attempting to create it.. EPSS estimates a 0.70% chance of exploitation in the next 30 days.

Description

The package com.github.samtools:htsjdk before 3.0.1 are vulnerable to Creation of Temporary File in Directory with Insecure Permissions due to the createTempDir() function in util/IOUtil.java not checking for the existence of the temporary directory before attempting to create it.

Metrics

CVSS 3.1

7.8/10

CVSS:3.1/AV:L/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H

EPSS Probability

0.70%

48.4th percentile

Probability of exploitation in the next 30 days. Learn more

Weakness Enumeration

CWE-668

Affected Software

Vendor	Product	Versions
Samtools	Htsjdk	< 3.0.1

References

https://github.com/samtools/htsjdk/commit/4a4024a97ee3e87096df6ad9b22c8260bd527772Patch, Third Party Advisory
https://github.com/samtools/htsjdk/pull/1617Exploit, Patch, Third Party Advisory
https://security.snyk.io/vuln/SNYK-JAVA-COMGITHUBSAMTOOLS-3149901Third Party Advisory
https://github.com/samtools/htsjdk/commit/4a4024a97ee3e87096df6ad9b22c8260bd527772Patch, Third Party Advisory
https://github.com/samtools/htsjdk/pull/1617Exploit, Patch, Third Party Advisory
https://security.snyk.io/vuln/SNYK-JAVA-COMGITHUBSAMTOOLS-3149901Third Party Advisory

Timeline

Published: Nov 29, 2022
Last Modified: Jun 17, 2026
Status: Modified

Frequently Asked Questions

What is CVE-2022-21126?

How severe is CVE-2022-21126?

CVE-2022-21126 has a CVSS score of 7.8/10 (HIGH severity). The EPSS model estimates a 0.70% probability of exploitation in the next 30 days.

How do I fix CVE-2022-21126?

Check the vendor references and advisories linked above for patched versions and mitigation guidance. You can also run a Strix scan to test if your systems are affected.

Are you affected by CVE-2022-21126?

Run a free Strix scan to check your systems for this vulnerability.

Scan your code now

Source: NVD / NIST