CVE-2025-12921

Name: CVE-2025-12921
Creator: NVD / NIST
Published: 2025-11-10T00:15:44.943+00:00
License: https://creativecommons.org/publicdomain/zero/1.0/

LOWCVSS 2.1/10EPSS 0.46%

Last modified Jun 17, 2026

CVE-2025-12921 is a low-severity vulnerability rated 2.1/10 on the CVSS scale. A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. EPSS estimates a 0.46% chance of exploitation in the next 30 days.

Description

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

Metrics

CVSS 3.1

8.8/10

CVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H

CVSS 4.0

2.1/10

CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:P/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X

EPSS Probability

0.46%

36.7th percentile

Probability of exploitation in the next 30 days. Learn more

Weakness Enumeration

Affected Software

Vendor	Product	Versions
Openclinica	Openclinica	3.12.2
Openclinica	Openclinica	3.13

References

https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.mdExploit, Third Party Advisory
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#pocExploit, Third Party Advisory
https://vuldb.com/?ctiid.331641Permissions Required, VDB Entry
https://vuldb.com/?id.331641Third Party Advisory, VDB Entry
https://vuldb.com/?submit.680872Third Party Advisory, VDB Entry
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.mdExploit, Third Party Advisory
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#pocExploit, Third Party Advisory

Timeline

Published: Nov 10, 2025
Last Modified: Jun 17, 2026
Status: Analyzed

Frequently Asked Questions

What is CVE-2025-12921?

How severe is CVE-2025-12921?

CVE-2025-12921 has a CVSS score of 2.1/10 (LOW severity). The EPSS model estimates a 0.46% probability of exploitation in the next 30 days.

How do I fix CVE-2025-12921?

Check the vendor references and advisories linked above for patched versions and mitigation guidance. You can also run a Strix scan to test if your systems are affected.

Are you affected by CVE-2025-12921?

Run a free Strix scan to check your systems for this vulnerability.

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Source: NVD / NIST