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CVE-2026-54604

MEDIUMCVSS 5.3/10EPSS 0.30%

Last modified

CVE-2026-54604 is a medium-severity vulnerability rated 5.3/10 on the CVSS scale. OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). EPSS estimates a 0.30% chance of exploitation in the next 30 days.

Description

OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.

Metrics

CVSS 4.0
5.3/10

CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X

EPSS Probability
0.30%

22.9th percentile

Probability of exploitation in the next 30 days. Learn more

Weakness Enumeration

Affected Software

Source: CNA advisory (CVE.org). NVD analysis pending.

VendorProductVersions
openslideopenslide< 4.0.1

References

Timeline

Published
Last Modified
Status
Awaiting Analysis

Frequently Asked Questions

What is CVE-2026-54604?
OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.
How severe is CVE-2026-54604?
CVE-2026-54604 has a CVSS score of 5.3/10 (MEDIUM severity). The EPSS model estimates a 0.30% probability of exploitation in the next 30 days.
How do I fix CVE-2026-54604?
Check the vendor references and advisories linked above for patched versions and mitigation guidance. You can also run a Strix scan to test if your systems are affected.

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Source: NVD / NIST